Precious cargo transportation software3/21/2023 ![]() "Transport of cargoes by motors is a tightly coordinated process, and yet the molecular mechanisms that control these 'engines' along the microtubule tracks remain largely unknown," says the study's first author, Rupkatha Banerjee, Ph.D., a postdoctoral research associate at Scripps Research in Florida who completed her doctorate in biological sciences at UB. We are super excited, since now we know how to control the 'engine' while it is moving on a track," says senior author Shermali Gunawardena, Ph.D., an associate professor of biological sciences in the University at Buffalo (UB) College of Arts and Sciences. "Our publication details how GSK3β attaches a molecular tag to kinesin 1 motors, which causes the motors to stop without detaching from microtubule tracks. In a study published in December 2021 in the journal Development, researchers describe how an enzyme called GSK3β can act as a stop switch for a type of motor protein called kinesin 1. Now, scientists have identified a new tool for traffic control. When the system breaks down, it can impede cellular function and lead to cell death. ![]() This miniature highway system is vital for keeping neurons healthy: When traffic is flowing well, critical materials are able to reach distant areas of the cells where they're needed. ![]()
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